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Eighth-year reports, like the one President Obama will deliver this week, have carried a special portent and the opportunity for a president to address his own record and the direction of the country.

Medications for heartburn called proton pump inhibitors are linked to a higher risk for chronic kidney disease, according to a study. It's the latest in a growing list of worries with these drugs.

A U.N.-brokered deal allowed supplies into the towns under siege by the Syrian regime. In the town of Madaya, food aid has been blocked since October and there have been reports of starvation deaths.

The Crimson Tide and the Clemson Tigers, both better known for their defense, played a high-scoring game Monday night, with Alabama using long passes and an onside kick to get a 45-40 win.

But for thousands of Somali refugees, the camp in Dadaab, Kenya, is the only home they've ever known.

The NFL could announce a decision this week on whether football will return to Los Angeles. Two proposals have generated the most buzz, involving the move of existing teams to new proposed stadiums in the cities of Carson or Inglewood. Owners are meeting this week to discuss the plans.

The economy has improved dramatically in the Obama era. But problems still abound because of the soaring national debt, a deformed tax code, shrunken paychecks and a growing skills gap.

It could be weeks before investigators can get in to what's left of a historic Old Market building following a weekend fire. The explosion and three-alarm…

President Obama hopes to use the speech to frame his last year in office and the 2016 campaign. The political spotlight, however, is increasingly shifting to the people running to replace him.

Steve Inskeep talks to Bayan Sami Abdul Rahman the Kurdish Regional Government's representative to the U.S. about what that region needs in the way of assistance as it fights against ISIS.